Chemists at MV Lomonosov Moscow State University of Moscow (MSU) have developed a genetic test that can be used to predict the development of bladder cancer ten years before the clinical detection of a tumor using a urinalysis. This was reported by the university press service.
In the genes of tumor cells, mutations that activate telomerase are detected, an enzyme that adds repeating DNA sequences at the terminal sections of chromosomes (telomeres). Typically, when dividing cells, telomeres are shortened, and when a certain length is reached, the cell stops dividing. However, if telomerase will constantly increase the length of telomeres, then such a cell will divide indefinitely and grow into a malignant tumor.
It is noted that a test by Russian scientists recognizes the corresponding mutations in the DNA of epithelial cells lining the bladder. They are found in urine; therefore, invasive procedures are not required for diagnosis.